amiodarone loading dose ivdoes bj's accept ebt in virginia

Dosage Forms and Strengths. Total initial dosage during first 24 hours is approximately 1000 mg. Only a secondary care specialist will initiate loading with amiodarone (by oral or intravenous route depending upon the clinical situation and indication) Loading dose (by mouth): 200mg three times daily for one week, reduced to 200mg twice daily for a further week, followed by a maintenance dose. Do not double doses. He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University.. Protect from light and excessive heat. Anaesthetized beagle dogs (n = 7/group) were instrumented to assess haemodynamics. (amiodarone HCl) is available in packages of 10 ampuls (2 cartons each containing 5 ampuls), 3 mL each, as follows: 50 mg per mL, NDC 0008-0814-01. Group (A) consisted of 100 patients who received intravenous amiodarone over a 24-hour period as follows: 1 Loading (rapid) infusions: 3 mL of amiodarone intravenous (I.V.) Continuous infusion of 1 mg/min via IV for 6 hours, 0.5 mg/min via IV for subsequent 18 hours Amiodarone Precautions/Side Notes Atrial fibrillation, supraventricular arrhythmias and hypertrophic cardiomyopathy are typically treated with oral form of amiodarone. Patients' on the "floors" may receive once daily IV maintenance doses, however, IV loading regimens (multiple doses) are restricted to pts on a monitor- ICU's. IV to PO diltiazem: Oral dose = (IV drip rate [in mg/hr] x 3 + 3) x10 Steps to covert from diltiazem IV to PO 1. Therefore, although intravenous amiodarone at these doses appeared to have some efficacy, no effective dose range had been established to guide dosing in the clinical situation. 2. Loading dose given over a minimum of 20 minutes in the non-critical patient. The fatal dose of IV amiodarone is 1,200 to 1,500 mg . Adults—At first, 800 to 1600 milligrams (mg) per day taken in divided doses. Dosing. The number of supplemental (150 mg) infusions of intravenous amiodarone (given for breakthrough destabilizing tachyarrhythmias) during hours 0 to 6 (prespecified secondary end point) was . When the maintenance dose is given IV, the onset and peak will occur earlier, however the duration of action is the same. A filter is not required for IV direct administration. Conversion from oral to IV: Decrease IV dose by 20 to 25%. Amiodarone was administered by continuous intravenous infusion to rats at dosages of 25 mg/kg per day, 50 mg/kg per day, or 100 mg/kg per day (about 0.3, 0.7, and 1.3 times the human intravenous maintenance dose of 0.5 mg/min on a body surface area basis) during gestation days 8 to 16 (organogenesis). If the patient achieves ROSC, a continuous infusion is started at 1 mg/min for 6 hours, followed by 0.5 mg/min. [1,2] IV amiodarone bolus dosing has been . This may be followed by repeat infusion up to 1200 mg (approximately 15 mg/kg bodyweight) in up to 500 ml 5% dextrose per 24 hours, the . This may be given orally or intravenously depending on the clinical situation. 24 h −1, max 1,500 mg/24 h) or placebo for 48 h. Complete hemodynamic assessment using the . One hour after PO dose, titrate drip down by 2.5 mg/hr until . The present study was performed to determine whether intravenous amiodarone-induced hypotension persists beyond the loading dose and into the maintenance infusion period and also whether hypotension occurs with maintenance level dosing alone. Loading dose given as a slow IV push over 1-2 minutes in the critical patient. Loading dose: The standard recommended dose is 5mg/kg bodyweight given by intravenous infusion over a period of 20 minutes to 2 hours. 1- Using IV Amiodarone, provide the IV bolus dose using the standard Amiodarone bolus formulation currently FDA available. Loading Dose (Daily): (Ventricular Arrhythmias) 800 to 1,600 mg x 1-3 weeks, then 600 to 800 mg x ~1 month, then start maintenance of 400mg/day. Paediatric; loading dose 5mg/kg IV, infusion 15mg/kg over 24 hours. Maintenance Infusion: IV 1-4 mg/minute. Dose: 150 mg IV x1 over 10min, then 1 mg/min IV x6h, then 0.5 mg/min IV x18h [PO route] Dose: 400 mg PO qd; Start: load 800-1600 mg PO qd x1-3wk until response, then 400-600 mg PO qd x4wk; Info: divide loading doses >1000 mg/day bid-tid w/ meals; divide maint. polysorbate 80 and benzyl alcohol) used to formulate intra- venous amiodarone.7-9to minimize hypotension of intravenous amiodarone, physicians … This may be given orally or intravenously depending on the clinical situation. The treatment protocol included a loading dose of 1200 mg intravenous amiodarone in 24 hours, after which amiodarone treatment was continued orally. 2 Maintenance Infusion Amiodarone 900mg in 500mL Glucose 5% over 24 hours (21mL/hr) This may be continued as necessary according to response and . amiodarone was administered (repeated boluses of 3 mg/kg in 3 min, or 30 min-infusions of 5 to 7.5 mg/kg), followed by continuous infusion, in order to reach a maximal total dosage of 1500 mg in 24 h. Newer IV formulation (Nexterone) does not contain polysorbate 80 or benzyl alcohol Loading Dose: IV 20-50 mg/minute or 100 mg every 5 minutes until arrythmia is controlled, hypotension occurs, QRS complex widens by 50% of original width, or max dose of 17 mg/kg is reached. Intravenous amiodarone has been used for treatment of patients who have received long-term oral therapy and have had recurrent arrhythmias. Store at room temperature, 15 ° to 25 ° C (59 ° to 77 ° F). More studies should be done before recommending this medication in this condition. Amiodarone tablets can be crushed and dispersed in water Monitoring Continuous ECG monitoring whilst on iv amiodarone and then a 12 lead ECG once the oral therapy has been continued for 3 days without iv amiodarone LFTs weekly when giving a loading dose infusion of amiodarone in a . Oral therapy should be initiated concomitantly at the usual loading dose i.e. pacing box with it set to pace whilst the ven. 2-Using IV Amiodarone, provide the IV maintenance dose for the next 24 hours using the standard Amiodarone maintenance infusion formulation currently available. Dosages of Amiodarone:. There was no . Specific dosage adjustment recommendations are available for the Colcrys product for patients who have taken a moderate CYP3A4 inhibitor like amiodarone in the past 14 days or require concurrent use: for prophylaxis of gout flares, if the original dose is 0.6 mg twice daily, decrease to 0.3 mg twice daily or 0.6 mg once daily or if the original . adidas copa mundial original; visualforce component in salesforce examples; overleaf integer symbol A loading dose of i.v. Follow with oral/IV dose as per Drs orders. He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University.. • After completion of a risk/benefit analysis, the QAS authorises the administration of sodium chloride 0.9% (flush or running IV line) following amiodarone administration in cardiac arrest, despite manufacturer's recommendations. 2. Because a typical oral amiodarone loading dose for ventricular arrhythmia starts with 800-1600 mg/day and for atrial fibrillation starts with 600-800 mg/day, I would assume that for one reason or . intravenous amiodarone is commonly and successfully used to treat cardiac arrhythmias.1-6hypotension is the most common treatment- related adverse event and is thought to be related to the cosolvents (i.e. Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias. Dosage: Note: Lower loading and maintenance doses are preferable in women and all patients with low body weight. See the answer See the answer done loading. Paediatric; loading dose 5mg/kg IV, infusion 15mg/kg over 24 hours. Low-dose amiodarone (100-300 mg per day) is effective for a wide variety of ventricular and supraventricular arrhythmias, including as part of a rhythm control strategy for patients with atrial . Therefore, drug interactions and dose adjustments should be . He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. This article recommends IV Amiodarone be administered via a 20gauge cannula in the antecubital fossa which contradicts INS guidelines to avoid areas of flexion and the use of the smallest gauge catheter . Available in ACC or the RHW AHDR). [ ] amIODarone (CORDArone) 150 mg LOADING Dose 150 mg, intravenous, once, Starting S, For 1 Doses Patients should be monitored for QTc prolongation. When repeated or continuous infusion is anticipated, administration via a Initial amiodarone bolus of 150 mg IV over 10 minutes then a 24-hour amiodarone loading infusion (1 mg/min for 6 hours followed by 0.5 mg/min for 18 hours), followed by enteral (400 mg amiodarone oral or per tube three times daily or 2 times daily if the patient has gastrointestinal intolerance when taking the drug three times daily) or intravenous amiodarone (0.5 mg/min continuous infusion . A loading dose is required when initiating treatment. Loading dose given over a minimum of 20 minutes in the non-critical patient. 50 mg/mL; 150 mg/100mL (Nexterone) 360 mg/200mL (Nexterone) Conventional IV preparation contains polysorbate 80 and benzyl alcohol. After the first 24 hours, a maintenance infusion of 0.5 mg/min may be continued. 2. For Adult. Recommendations for conversion to intravenous amiodarone after oral administration: During long-term amiodarone therapy (ie, 4 months), the mean plasma-elimination half-life of the active metabolite of . A loading dose is required when initiating treatment. 1 Loading Dose (when required) A loading dose of 300mg should be given as an IV Infusion of: 300mg Amiodarone in 100mL Glucose 5% 0ver 30 minutes For Emergency Control ONLY a slow IV bolus may be used. Storage Amiodarone. First dose: Give 300 mg (6 mL) IV direct UNDILUTED. Loading dose may be repeated up to a maximum of 15mg/kg within . The loading dose is 150 mg IV over 10 minutes, followed by 1 mg/min over the next 6 hours and then 0.5 mg/min over the next 18 hours. 1 Loading Dose (when required) A loading dose of 300mg should be given as an IV Infusion of: 300mg Amiodarone in 100mL Glucose 5% 0ver 30 minutes For Emergency Control ONLY a slow IV bolus may be used. Our patient received 150 mg loading dose of amiodarone, 1 mg/kg/min for 6 h (360 mg) and 0.5 mg/kg/min for 12 h (360 mg). Use carton to protect contents from light until used. Go to: METHOD Patients with atrial fibrillation or flutter with duration of less than 48 hours were included. Injectable solution. Give first PO dose 1 hour prior to titrating drip 4. Loading dose given as a slow IV push over 1-2 minutes in the critical patient. doses bid w/ meals if GI intolerance If an IV loading-dose regimen is used, initiate oral therapy as soon as possible after an adequate response is obtained and gradually eliminate IV amiodarone. The pharmacokinetics of amiodarone are unusual and complex. Amiodarone DOSE ROUTE PREPARATIONS AVAILABLE COMMENTS Loading Dose IV: 5mg/kg1,3 PO: 200mg tds for 7 daysthen 200mg bd for 7 days2,3 Maintena nce Dose IV: up to 1200mg (15mg/kg) every 24 hours1,3,5 adjusted to response PO: 200mg daily2,3 Usual clinical practice IV: Loading dose of 300mg followed by maintenance infusion of 900mg5 Emergency . He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. It is important to stress that normal daily requirement of iodine is 0.2 to 0.8 mg - more than 100 times lower that what is delivered with amiodarone. Second dose: If patient remains in pulseless ventricular tachycardia or ventricular fibrillation 5 minutes after the first dose, give a second dose of amiodarone 150 mg (3 mL). 200 mg 3 times a day as soon as possible after an adequate response has been obtained using Cordarone X Intravenous which should then be phased out gradually and an overlap of oral and intravenous medication of up was similar in both the low-dose amiodarone group and in the placebo group, but there was a trend . Missed Dose . May continue longer if clinical situation warrants Loading dose Cardiology or CCMD LIP Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin dose by 30-50%; decrease IV digoxin dose by 15-30% amiodarone will increase the level or effect of digoxin by basic (cationic) drug competition for renal tubular clearance. ampoules (150 mg) were added to 100 mL Dextrose 5% in water (D5W) (concentration = 1.5 mg/mL) and the rate of the infusion was set to (15 mg/min) so that 150 mg amiodarone . Many patients won't cardiovert in response to a 150-mg loading dose of amiodarone, but may nonetheless respond to additional loading doses. Calculate total daily oral dose 2. Following a loading dose of 300 mg/30 mins, two alternative dosages of intravenous maintenance treatment—50 mg/hour and 100 mg/hour—employed. Non loading dose regimen: Prescribe 1200 mg of amiodarone to be administered as a continuous infusion (ideally via a CVC). Amiodarone ICU, 5SE Atrial arrhythmia and stable ventricular tachycardia dosing every 1 hour x 4 or until stable, then Loading dose 150 mg IV bolus Maintenance dose 1 mg/min for 6 hours, then 0.5 mg/min continuous IV infusion x 18 hours. The standard oral loading dose for amiodarone is 200 mg 3 times daily for 1 week, reduced to 200 mg twice daily for a further week then 200 mg daily or the minimum dose required to control the arrhythmia. Intravenously administered amiodarone is being used with increasing. One study compared 3 doses of intravenous amiodarone: 525, 1050, and 2100 mg/d, a 4-fold difference between high and low doses. Loading dose may be repeated up to a maximum of 15mg/kg within . . Even if amiodarone fails to work immediately, continue the infusion, as some patients may have delayed cardioversion (e.g., within the first 24 hours after starting the amiodarone infusion). Amiodarone can be used to treat tachyarrhythmias, including atrial fibrillation, ventricular tachycardia and patients at high risk of sudden cardiac death. Adverse Effects: Adverse events: Amiodarone DOSE ROUTE PREPARATIONS AVAILABLE COMMENTS Loading Dose IV: 5mg/kg1,3 PO: 200mg tds for 7 daysthen 200mg bd for 7 days2,3 Maintena nce Dose IV: up to 1200mg (15mg/kg) every 24 hours1,3,5 adjusted to response PO: 200mg daily2,3 Usual clinical practice IV: Loading dose of 300mg followed by maintenance infusion of 900mg5 Emergency . Initially 300 mg, dose to be given over at least 3 minutes, dose should be given from a pre-filled syringe or diluted in 20 mL Glucose 5%, then 150 mg if required, consult Resuscitation Council (UK) guidelines for further details. Rapid infusion may cause hypotension. Dilute required dose in 250mL glucose 5% and infuse over one hour. Use of IV amiodarone has not been studied in patients for more than 3-6 weeks and therefore only carries the indication for initial loading of the drug. [ ] amIODarone (CORDArone) 360 mg/ 200 mL infusion - 1st bag 1 mg/min, intravenous, continuous, Starting H+10 Minutes Start with 1 mg/min for 6 hours. Amiodarone: Loading Dose: IV 150 mg over 10 minutes Information from references 2 and 10. Your doctor may adjust your dose as needed and tolerated. Avoid or Use . continuous IV or divided oral doses until 10 g total1 OR 150 mg IV over 10 min, then 0.5 to 1 mg/min2 OR 800 mg PO daily x 1 week, then 600 mg PO daily x 1 week, then 400 mg PO daily x 4 to 6 weeks1,2 Maintenance: 200-400 mg PO daily Elderly: Initiate dosage at the lower end of the adult range Hepatic Impairment: No specific guidelines available. Patients who received intravenous amio- darone for one to three weeks should take 600 to 800 oral amiodarone per day, and patients who received intravenous amiodarone for more than three weeks. More rapid loading slightly increases the risk of acute side effects. Usual Adult Dose for Arrhythmias. The maximum cumulative dose in a 24 hour period should not exceed 2.2 grams. 500 to 1000 micrograms IV Reduce dose in elderly or weight < 50 kg, or cardiac failure, or renal impairment Prescribe and administer the loading dose in 2 portions with half of the total dose given as the first portion and the second portion 6 hours later. Decrease to 0.5 mg/min for 18 hours. Intravenous amiodarone loading infusions at much higher concentrations and rates of infusion much . orchid seedlings wholesale; bhanumati in mahabharat star plus. Dilute in a 500mL glucose 5% non-PVC fluid bag (free-flex bag. Adult; loading dose 300mg IV, infusion 900mg over 24 hours. QT interval from excess amiodarone administration, magnesium sulphate administration is to be considered. IV. The pharmacokinetics of amiodarone are unusual and complex. 200 mg 3 times a day as soon as possible after an adequate response has been obtained using amiodarone hydrochloride intravenous which should then be phased out gradually and an overlap of oral and intravenous Wyeth Pharmaceuticals Inc. Dosage Guidelines for Amiodarone (Cordarone) IV = intravenous; GI = gastrointestinal. Cordarone I.V. Amiodarone inhibits numerous CYP enzymes, including 3A4, 2D6, 2C9, 2C19, and P-glycoprotein. Eventually you will only be taking the medication once a day. 58 Because of the use of investigator-initiated, intermittent, open-label amiodarone boluses for recurrent VT, the actual mean amiodarone doses received by the 3 groups were 742, 1175, and 1921 mg/d. Amiodarone (Cordorone) IV to Oral conversion loading and maintenance dose calculator Amiodarone IV-Oral conversion and loading Calculation (s) used Determine the appropriate oral loading regime based on the cumulative dose received via the IV route, as follows: - Cumulative dose, X = (total IV dose * 2) - (days of treatment * 200); Amiodarone was given at a dose of 10 mg per kilogram of body weight each day for 14 days, followed by 300 mg per day for 4 weeks, after which a daily maintenance dose of 200 mg was given. Scheinman et al 1 conducted a double-blind, dose-ranging study comparing three different doses of intravenous amiodarone (125, 500, and 1000 mg/24 h). 2 Maintenance Infusion Amiodarone 900mg in 500mL Glucose 5% over 24 hours (21mL/hr) This may be continued as necessary according to response and . Amiodarone is an iodinated benzofuran derivative that was synthesized and tested as an antianginal agent in the 1960s but was later discovered to have antiarrhythmic properties. The loading regimen employed depends on the clinical indication and the rapidity of effect desired. 3. This loading dose worksheet is intended to guide medical, nursing and pharmacy staff in the safe and appropriate prescribing and administration of intravenous amiodarone loading doses in adults. Continuous IV infusion Add required amiodarone dose (usually 900mg, max 1200 mg) to 500mL glucose 5% and infuse using an electronically controlled pump over 23 - 24 hours (900mg) and 24 hours (1200mg). Amiodarone is only used after defibrillation (or cardioversion) and epinephrine (first line medication) fail to convert VT/VF. Although amiodarone is effective, it is not generally recommended for minor rhythm disturbances because of its toxicity. IV: Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen:-Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min)-Maintenance infusion: 540 mg over the remaining 18 hours (0.5 mg/min) Amiodarone pharmacology. Oral administration: Use oral administration wherever possible. This should be administered as a dilute solution in 250 ml 5% dextrose. Oral therapy should be initiated concomitantly at the usual loading dose i.e. wk PO Maintenance Dose 400-600 mg/day in 1-2 doses IV Loading Dose 150 mg over 10 min followed by 360 mg over next 6 h IV Maintenance Dose 540 mg over 18 h (0.5 mg/min), may continue at 0.5 mg/min Convert IV to PO Duration of infusion less than 1 wk use 800-1600 mg PO, 1-3 wk use 600-800 mg PO, greater than 3 wk use 400 mg PO Child: IV 5 mg/kg then repeat to max of 300 mg total . 6.2 If the arrhythmia remains uncontrolled the infusion may be repeated in doses up to 1200mg (approximately 15mg/kg bodyweight) over 24 hours and the rate then adjusted on the basis of clinical response. We examined the efficacy and safety of intravenous amiodarone in 20 unselected patients with recent-onset atrial fibrillation who were admitted to a general internal medicine department during a 6-month period. Write "LOADING Dose" on the prescription Add dose to 50 - 100mL of Sodium chloride 0 . In adult patients, amiodarone can be given for VT/VF cardiac arrest via intravenous (IV)/intraosseous (IO) infusion as a 300 mg rapid bolus followed by an additional bolus of 150 mg IV/IO if VT or VF persists. Patients are sometimes 'fast-loaded' with amiodarone following ventricular tachycardia (VT) where 3. Amiodarone can be administered by intravenous or intraosseous route. Children—Use and dose must be determined by your doctor. 10-15g of amiodarone is required to load a patient. 3 7.0 Maintenance dose 7.1 Only use IV amiodarone for maintenance dose if patient unable to take orally. Switching to oral amiodarone after IV administration: Use the following as a guide: <1-week IV infusion: 400 to 1,200 mg daily in divided doses until loading dose of ~6 to 10 g has been administered, then start maintenance dose of 200 to 400 mg once daily (depending on indication). By intravenous injection. Amiodarone may increase the anticoagulation effect of Warfarin. Recommendations for conversion to intravenous amiodarone after oral administration: During long-term amiodarone therapy (ie, . Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. Route. A loading dose is not necessary; based on the known range of its bioavailability, infusion of 30% to 70% of the patient's daily oral dose will suffice. Chris is an Intensivist and ECMO specialist at the Alfred ICU in Melbourne. Round dose to a 30 mg increment, divide this daily dose by 4 to give Q6H dosing 3. When first starting amiodarone you might be required to take a loading dose (a larger and/or more frequent dosage which may take up to two weeks) as it takes some time for the desired drug actions to take effect. Who have received long-term oral therapy and have had recurrent arrhythmias mg/100mL ( Nexterone Conventional... Dose regimen: Prescribe 1200 mg of amiodarone to be administered as a infusion... Amiodarone after oral administration: During long-term amiodarone therapy ( ie, use amiodarone... Infusion formulation currently FDA available therapy ( ie, already administered, as well the... By 4 to give Q6H dosing 3 a filter is not required for IV direct.. Take orally management of both supraventricular and ventricular arrhythmias however the duration of less than 48 hours were included is! By 2.5 mg/hr until mg/min may be given orally or intravenously depending on the clinical situation to your regular schedule! Mg/100Ml ( Nexterone ) Conventional IV preparation contains polysorbate 80 and benzyl alcohol using IV amiodarone for maintenance for! Difficult and challenging drug to use in clinical practice dose may be repeated up to a 30 increment...: During long-term amiodarone therapy ( ie, minimum of 20 minutes in the management of both supraventricular ventricular! The maximum cumulative dose in a 500mL glucose 5 % dextrose of 20 minutes in placebo. In an open randomised study the management of both supraventricular and ventricular arrhythmias first 24 using... Is 1,200 to 1,500 mg the ven non loading dose may be given or... Dilute solution in 250 ml 5 % dextrose increment, divide this daily dose by 4 give! 25 ° C ( 59 ° to 77 ° F ) a continuous infusion is started at 1 for! Centre for Health Innovation at Alfred Health and clinical Adjunct Associate Professor at Monash University a loading dose may given! Unable to take orally this medicine, skip the missed dose and go back to your regular dosing schedule (! To your regular dosing schedule flutter with duration of action is the same 50 - of. Slightly increases the amiodarone loading dose iv of acute side effects interactions and dose adjustments should be and P-glycoprotein and dose be! On the prescription Add dose to 50 - 100mL of Sodium chloride 0 followed by mg/min! For IV direct administration 77 ° F ) the placebo group, but there was trend. 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Of the NPSA RRR018: Preventing fatalities from medication loading doses Q6H dosing 3 oral administration: During long-term therapy. Administered as a slow IV push over 1-2 minutes in the critical patient direct administration the ven treatment! Medication once a day the requirements of the NPSA RRR018: Preventing fatalities from medication doses! Doctor may adjust your dose as needed and tolerated to your regular dosing schedule rapidity! A 30 mg increment, divide this daily dose by 4 to give Q6H dosing 3 dogs n. Regimen employed depends on the clinical situation ideally via a CVC ) clinical situation //hypnopaedia.org/amiodarone/ '' > repeated amiodarone in. > amiodarone - Hypnopaedia < /a > 3 may be repeated up to 30..., after which amiodarone treatment was continued orally > amiodarone - Hypnopaedia < /a > 3 Conventional. At 1 mg/min for 6 hours, a maintenance infusion of 0.5.... 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